This item contains much information about his various posts and about conflicts, personalities, and the politics of science. There are also many references and comments about scientific technology of the day, and of such people as Matthew F. Maury. There are numerous letters to A. D. Bache, James Henry Coffin, Charles Henry Davis, and William H. Willcox.

This collection contains primarily professional correspondence and papers, but there is substantial material concerning Shryock family history. Most of the collection relates to Shryock's intellectual and social life at the University of Pennsylvania, Duke University, and Johns Hopkins University-- institutions where he made contributions as a professor of history and especially as a medical historian.